Microcrystal manipulation with laser tweezers
نویسندگان
چکیده
منابع مشابه
Microcrystal manipulation with laser tweezers
X-ray crystallography is the method of choice to deduce atomic resolution structural information from macromolecules. In recent years, significant investments in structural genomics initiatives have been undertaken to automate all steps in X-ray crystallography from protein expression to structure solution. Robotic systems are widely used to prepare crystallization screens and change samples on...
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b) Atoms have some probability of absorbing photons from the laser beam, thereby being kicked along the direction of the beam. This processes can be modelled classically by supposing that the polarizability of the atom has an imaginary part: α = α′ + iα′′. Deduce the (time-averaged) force on an atom along the direction of propagation of a linearly polarized plane electromagnetic wave in terms o...
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1. – Introduction Proteins must fold into compact and unique three-dimensional structures to carry out their specific functions. If folding goes wrong, proteins become useless and often toxic molecules for living cells. Millions of people around the world suffer from diseases caused by protein misfolding, such as Gaucher’s disease, Alzheimer’s disease and Parkinson’s disease [1, 2]. Despite its...
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In summary, we described the use of laser scissors and tweezers from three perspectives: (a) the historical background from which these two techniques evolved, (b) an understanding and lack of understanding of the mechanisms of interaction with the biological systems, and (c) the applications of the scissors and tweezers alone and in combination. As the technology improves and we gain a better ...
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Optical droplet manipulation techniques typically generate small forces or require special substrates. This paper describes the concept of an optofluidic tweezer, where focused light energy at the interface of an oil droplet and its carrier fluid generates balanced thermocapillary flows which trap the droplet. The forces are attractive, and the large magnitudes (on the order of μN) enables the ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2008
ISSN: 0108-7673
DOI: 10.1107/s0108767308096360